Drug release behaviour and mechanism from unmodified and in situ modified bacterial cellulose

Bacterial cellulose (BC) is a suitable drug delivery carrier owing to the nanofibrous micro and mesoporous structure. One of unique aspects tunability BC microstructure by addition certain additives in growth medium during synthesis bacteria. In present work, was situ modified adding Polyethylene glycol 2000 (PEG 2000). Effect modification on crystallinity, chemical composition, morphology and, porosity studied XRD, FTIR, SEM BET, followed effect (Diclofenac sodium) loading release kinetics. As non-incorporating modifier, PEG2000 increased overall porosity, pore volume decreased specific surface area with no significant crystallinity. vitro, studies revealed that huge burst for PEG as compared pristine BC. The mechanism further investigated mathematical modelling. This work opens up avenues exploring wide possibility tuning immediate sustained from bacterial various applications.